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Palladium‐Catalyzed Decarboxylative Synthesis of 5 H ‐Benzo[4,5][1,3]oxazino[2,3‐ a ]isoindole‐5,11(6a H )‐Diones using 2‐Phenyl‐4 H ‐Benzo[ d ][1,3]oxazin‐4‐Ones and α‐Oxo Carboxylic Acids
Author(s) -
Lalji Ram Sunil Kumar,
Kumar Prashant,
Gupta Mohit,
Parmar Virinder S.,
Singh Brajendra K.
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901142
Subject(s) - isoindole , chemistry , palladium , catalysis , surface modification , stereochemistry , medicinal chemistry , organic chemistry
A Pd‐catalyzed novel and efficient protocol has been developed for the direct functionalization of 2‐phenyl‐4 H ‐benzo[ d ][1,3]oxazin‐4‐ones with α‐oxo carboxylic acids resulting in 5 H ‐benzo[4,5][1,3]oxazino[2,3‐ a ]isoindole‐5,11(6a H )‐diones using (NH 4 ) 2 S 2 O 8 as effective oxidant and AgNO 3 as co‐oxidant. All the explored substrates were found to be compatible for this transformation and delivered the corresponding desired products in moderate to excellent yields.