Cobalt‐Catalyzed Regioselective [4+2] Annulation/Lactonization of Benzamides with 4‐Hydroxy‐2‐Alkynoates under Aerobic Conditions | Zendy

Muniraj Nachimuthu | Zendy; Kumar Anil | Zendy; Prabhu Kandikere Ramaiah | Zendy

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Cobalt‐Catalyzed Regioselective [4+2] Annulation/Lactonization of Benzamides with 4‐Hydroxy‐2‐Alkynoates under Aerobic Conditions

Author(s) -

Muniraj Nachimuthu,

Kumar Anil,

Prabhu Kandikere Ramaiah

Publication year - 2020

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201901119

Subject(s) - regioselectivity , annulation , chemistry , isoquinoline , catalysis , cobalt , dehydrogenation , substrate (aquarium) , combinatorial chemistry , organic chemistry , reaction conditions , medicinal chemistry , stereochemistry , oceanography , geology

A cobalt‐catalyzed regioselective [4+2] annulation/lactonization reaction of benzamides with 4‐hydroxy‐2‐alkynoates is reported. This reaction utilizes air as an oxidant rather than metal salts. The method is operationally simple, mild, and sustainable. This protocol exhibits a broad substrate scope and compatible with a variety of functional groups furnishing the corresponding 1,4‐dihydrofuro[3,4‐ c ]isoquinoline‐3,5‐dione derivatives in good to excellent yields with high regioselectivity.

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