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Copper‐Catalyzed Domino Cyclization/Thiocyanation of Unactivated Olefins: Access to SCN‐Containing Pyrazolines
Author(s) -
Meng Fei,
Zhang Honglin,
He Han,
Xu Ning,
Fang Qin,
Guo Kang,
Cao Shujun,
Shi Yun,
Zhu Yingguang
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901104
Subject(s) - chemistry , domino , catalysis , cascade reaction , combinatorial chemistry , cascade , copper , reaction conditions , organic chemistry , chromatography
A mild and highly efficient Cu‐catalyzed cascade cyclization/thiocyanation of unactivated alkenes bearing hydrazones has been developed. A broad range of SCN‐substituted pyrazolines have been readily obtained in good to excellent yields with commercially available and very cheap Cu(acac) 2 and NH 4 SCN. This present method provides a rapid, facile, and practical access to valuable pyrazolines with the important SCN functionality, and it is amenable to the gram scale.