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Reaction of Cycloalkene‐1‐carboxamides with Aryl Boronates via Rhodium(III)‐Catalyzed C−H Activation: A Versatile Route to 3,4‐Cycloalkaquinolin‐2(1 H )‐ones
Author(s) -
Zhu YouQuan,
Hui LiWen,
Niu YunXia,
Lv LinGe,
Zhu Kun
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901047
Subject(s) - chemistry , rhodium , pinacol , aryl , catalysis , cycloalkene , surface modification , combinatorial chemistry , medicinal chemistry , organic chemistry , alkyl
Under rhodium(III) catalysis, substituted N ‐methoxycycloalkene‐1‐carboxamides successfully reacted with aryl boronic acid pinacol esters to provide 3,4‐cycloalkaquinolin‐2(1 H )‐ones via direct functionalization of the β‐alkenyl C−H bond and form C−C/C−N bond in one pot. The gram‐scale synthesis of the title compound demonstrated the great synthetic utility of this methodology.