Visible‐Light Facilitated Fluorescence “Switch‐On” Labelling of 5‐Formylpyrimidine RNA | Zendy

Wang RuiLi | Zendy; Jin XiaoYang | Zendy; Kong DeLong | Zendy; Chen ZhiGang | Zendy; Liu Ji | Zendy; Liu Li | Zendy; Cheng Liang | Zendy

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Visible‐Light Facilitated Fluorescence “Switch‐On” Labelling of 5‐Formylpyrimidine RNA

Author(s) -

Wang RuiLi,

Jin XiaoYang,

Kong DeLong,

Chen ZhiGang,

Liu Ji,

Liu Li,

Cheng Liang

Publication year - 2019

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201901032

Subject(s) - labelling , chemistry , fluorescence , rna , fluorescent light , cytidine , visible spectrum , fluorescent labelling , blue light , photochemistry , catalysis , biophysics , biochemistry , optoelectronics , optics , enzyme , physics , biology , gene

Labelling and detecting 5‐formylpyrimidine is essential to understand its biological function. Herein, we describe a visible‐light triggered and catalyst‐free reaction in which 5‐formylcytidine RNA can be selectively labelled with 2‐thioaniline under the irradiation of a commercial blue LED light to generate fluorogenic 5‐(benzothiazol‐2‐yl) cytidine.

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