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Visible‐Light Facilitated Fluorescence “Switch‐On” Labelling of 5‐Formylpyrimidine RNA
Author(s) -
Wang RuiLi,
Jin XiaoYang,
Kong DeLong,
Chen ZhiGang,
Liu Ji,
Liu Li,
Cheng Liang
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901032
Subject(s) - labelling , chemistry , fluorescence , rna , fluorescent light , cytidine , visible spectrum , fluorescent labelling , blue light , photochemistry , catalysis , biophysics , biochemistry , optoelectronics , optics , enzyme , physics , biology , gene
Labelling and detecting 5‐formylpyrimidine is essential to understand its biological function. Herein, we describe a visible‐light triggered and catalyst‐free reaction in which 5‐formylcytidine RNA can be selectively labelled with 2‐thioaniline under the irradiation of a commercial blue LED light to generate fluorogenic 5‐(benzothiazol‐2‐yl) cytidine.