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Metal‐Free Three‐Component Selenopheno[2,3‐ b ]indole Formation through Double C−H Selenylation with Selenium Powder
Author(s) -
Ni Penghui,
Tan Jing,
Zhao Wenqi,
Huang Huawen,
Deng GuoJun
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201901023
Subject(s) - chemistry , selenium , indole test , stereochemistry , metal , annulation , combinatorial chemistry , organic chemistry , catalysis
A facile metal‐free entry to novel selenopheno[2,3‐ b ]indole motif is described. The three‐component assembly of indoles, aromatic ketones, and selenium powder is enabled by the IBr‐promoted highly selective double C–H selenylation/annulation. This protocol provides a novel access to a diverse variety of selenopheno[2,3‐ b ]indoles with good efficacy and broad functional group compatibility.