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Visible Light‐Initiated Catalyst‐Free One‐Pot, Multicomponent Construction of 5‐Substituted Indole Chromeno[2,3‐ b ]pyridines
Author(s) -
Zhang Mo,
Chen MengNan,
Zhang ZhanHui
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900994
Subject(s) - malononitrile , chemistry , indole test , catalysis , functional group , aqueous solution , organic chemistry , combinatorial chemistry , polymer
A visible light‐initiated pseudo four‐component reaction of salicylaldehydes, indole and malononitrile in aqueous ethyl lactate is described. This pot, atomic and step economic (PASE) methodology provides a practical approach for the preparation of various 5‐substituted indole chromeno[2,3‐ b ]pyridines from readily available starting materials at ambient temperature without any catalyst. High yields and excellent functional groups tolerance are observed.