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Surgical Cleavage of Unstrained C( sp 3 )−C( sp 3 ) Bonds in General Alcohols for Heteroaryl C−H Alkylation and Acylation
Author(s) -
Wang Yaxin,
Yang Le,
Liu Shuai,
Huang Lixia,
Liu ZhongQuan
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900975
Subject(s) - chemistry , steric effects , alkylation , acylation , cleavage (geology) , bond cleavage , catalysis , medicinal chemistry , radical , alkyl , stereochemistry , carbon–carbon bond , selectivity , organic chemistry , geotechnical engineering , fracture (geology) , engineering
We reported herein a predictable and surgical cleavage of carbon‐carbon bond in alcohols. A wide range of 1°, 2° and 3° alcohols including sugars and steroids without ring strain or steric hindrance were all compatible with this system. Also it offered a green and practical strategy for generation of alkyl/acyl radicals using alcohols as the sources. Besides, the features of visible‐light‐initiation, catalyst and metal free, excellent selectivity and mild conditions make it valuable and attractive.