Premium
Front Cover Picture: An Efficient Route to Isochromene Derivatives via Cascade Radical Cyclization and Radical‐Radical Coupling (Adv. Synth. Catal. 18/2019)
Author(s) -
Yu Kaili,
Li Minyan,
Deng Guogang,
Liu Chunxiang,
Wang Jing,
Liu Zhengfen,
Zhang Hongbin,
Yang Xiaodong,
Walsh Patrick J.
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900926
Subject(s) - radical cyclization , chemistry , radical , allylic rearrangement , medicinal chemistry , cascade , catalysis , organic chemistry , chromatography
The front cover picture , designed by Xiaodong Yang, Patrick J. Walsh and co‐workers, illustrates a novel and efficient route to construct isochromene derivatives through a cascade radical cyclization strategy. Aryl radicals derived from SET between 2‐azaallyl anions and 2‐iodobenzyl allenyl ethers trigger a radical cyclization to construct the isochromene core with formation of an allylic radical. The allylic radical then undergoes coupling with the azaallyl radical to give the products in good to excellent yields. Details of this work can be found in the Update on pages 4354–4359 (K. Yu, M. Li, G. Deng, C. Liu, J. Wang, Z. Liu, H. Zhang, X. Yang, P. J. Walsh, Adv. Synth. Catal . 2019 , 361 , 4354–4359; DOI: 10.1002/adsc.201900497).