Premium
Ir‐catalyzed Asymmetric Hydrogenation of α‐Imino Esters with Chiral Ferrocenylphosphine‐Phosphoramidite Ligands
Author(s) -
Hu XinHu,
Hu XiangPing
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900888
Subject(s) - phosphoramidite , chemistry , asymmetric hydrogenation , catalysis , aryl , ligand (biochemistry) , combinatorial chemistry , optically active , glycine , chiral ligand , enantioselective synthesis , stereochemistry , organic chemistry , amino acid , receptor , oligonucleotide , dna , biochemistry , alkyl
An Ir‐catalyzed asymmetric hydrogenation of α‐imino esters with unsymmetrical hybrid chiral ferrocenylphosphine‐phosphoramidite ligands for the synthesis of optically active α‐aryl glycines has been described. The result indicated that the presence of the iodo‐substitutent at the 3/3’‐position of the binaphthyl unit of ligand could significantly improve the catalytic performance. This method features high asymmetric induction and reasonable functional group tolerance, thus providing a concise and efficient approach toward chiral α‐aryl glycine derivatives with up to 96% ee.