Redox Economic Synthesis of TrisubstitutedPiperidones via Ruthenium Catalyzed Atom‐Economic Couplings of N‐Protected 1,5‐Aminoalcohols and Michael Acceptors | Zendy

Trost Barry M. | Zendy; Sarkar Debayan | Zendy; Bera Nabakumar | Zendy

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Redox Economic Synthesis of TrisubstitutedPiperidones via Ruthenium Catalyzed Atom‐Economic Couplings of N‐Protected 1,5‐Aminoalcohols and Michael Acceptors

Author(s) -

Trost Barry M.,

Sarkar Debayan,

Bera Nabakumar

Publication year - 2019

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201900881

Subject(s) - chemistry , catalysis , ruthenium , ketone , michael reaction , base (topology) , atom economy , atom (system on chip) , combinatorial chemistry , redox , medicinal chemistry , organic chemistry , mathematical analysis , mathematics , computer science , embedded system

An efficient atom‐economic coupling of 1,5‐amino alcohols and Michael acceptors has been developed employing [CpRu(MeCN) 3 ]PF 6 as a key catalyst to synthesize α,β‐unsaturated ketones with exclusive generation of E ‐geometrical isomers at room temperature without any co‐catalyst and additives. A base catalysed 6‐ endo‐trig cyclization of the α,β‐unsaturated ketone delivers a direct access to tri‐substituted piperidones.

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