Tunable Single and Double γ‐C−H Arylation of Phenylacetamides Directed by o ‐Aminophenols

The cheap and easily available o ‐aminophenols (OAPs) have been identified as practical directing component for the Pd‐catalyzed aromatic γ‐C−H bond arylation of phenylacetamides. Notably, the selective single and double arylation of the C−H bond(s) in the γ‐potion has been independently realized by simply modifying reaction conditions. The catalytic system of Pd(CF 3 OO) 2 /K 2 S 2 O 8 /K 2 CO 3 enables the selective single C−H arylation. On the other hand, the catalysis of Pd(OAc) 2 in the presence of KIO 3 /K 2 CO 3 induces the selective arylation of both γ‐C−H bonds.