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Heterogeneous Catalytic Reduction of Tertiary Amides with Hydrosilanes Using Unsupported Nanoporous Gold Catalyst
Author(s) -
Zhao Yuhui,
Zhang Sheng,
Yamamoto Yoshinori,
Bao Ming,
Jin Tienan,
Terada Masahiro
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900838
Subject(s) - chemistry , catalysis , nanoporous , selective catalytic reduction , filtration (mathematics) , combinatorial chemistry , organic chemistry , statistics , mathematics
We have demonstrated that the unsupported nanoporous gold (AuNPore) was a green and highly efficient heterogeneous catalyst for the reduction of amides to amines using hydrosilanes as reductants. A variety of tertiary amides with a broad functional groups were reduced to the corresponding tertiary amines in the presence of 2 mol% of AuNPore and PheMe 2 SiH or (Me 2 SiH) 2 O under mild conditions. AuNPore catalyst was recovered by simple filtration and used for twelve times without any loss of catalytic activity. The AuNPore/hydrosilane system was also successfully applied to the hydrosilative reduction of sulfoxides and N ‐oxides.