TEMPO‐Mediated Synthesis of  N ‐(Fluoroalkyl)imidazolones via Reaction of Imidazoles with Iodofluoroacetate | Zendy

Chen JiaHao | Zendy; Ahmed Wasim | Zendy; Li MingHua | Zendy; Li ZhaoDong | Zendy; Cui ZiNing | Zendy; Tang RiYuan | Zendy

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TEMPO‐Mediated Synthesis of N ‐(Fluoroalkyl)imidazolones via Reaction of Imidazoles with Iodofluoroacetate

Author(s) -

Chen JiaHao,

Ahmed Wasim,

Li MingHua,

Li ZhaoDong,

Cui ZiNing,

Tang RiYuan

Publication year - 2020

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201900820

Subject(s) - chemistry , catalysis , copper , combinatorial chemistry , organic chemistry

We report a TEMPO‐mediated oxidative copper‐catalyzed synthesis of N ‐(fluoroalkyl)imidazolones via the radical addition of imidazoles with iodofluoroacetate. A possible key intermediate involving TEMPO was observed by ESI‐MS. We also found that aerobic oxidation conditions were effective for the transformation in the presence of a copper catalyst, enabling access to a number of N ‐(fluoroalkyl)imidazolones in moderate to good yields.

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