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TEMPO‐Mediated Synthesis of N ‐(Fluoroalkyl)imidazolones via Reaction of Imidazoles with Iodofluoroacetate
Author(s) -
Chen JiaHao,
Ahmed Wasim,
Li MingHua,
Li ZhaoDong,
Cui ZiNing,
Tang RiYuan
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900820
Subject(s) - chemistry , catalysis , copper , combinatorial chemistry , organic chemistry
We report a TEMPO‐mediated oxidative copper‐catalyzed synthesis of N ‐(fluoroalkyl)imidazolones via the radical addition of imidazoles with iodofluoroacetate. A possible key intermediate involving TEMPO was observed by ESI‐MS. We also found that aerobic oxidation conditions were effective for the transformation in the presence of a copper catalyst, enabling access to a number of N ‐(fluoroalkyl)imidazolones in moderate to good yields.