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Lewis Acid‐Mediated Cyanation of Phenols Using N ‐Cyano‐ N ‐phenyl‐ p‐ toluenesulfonamide
Author(s) -
Zhang Wu,
Li Tao,
Wang Qingli,
Zhao Wanxiang
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900813
Subject(s) - cyanation , chemistry , regioselectivity , phenols , phenol , lewis acids and bases , medicinal chemistry , organic chemistry , catalysis
Lewis acid‐mediated cyanation of phenol derivatives with N ‐cyano‐ N ‐phenyl‐ p ‐toluenesulfonamide (NCTS) has been developed. The reaction proceeded efficiently with high regioselectivity to produce aromatic nitriles in moderate to excellent yields, which provides a direct and practical access to valuable products.