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A Chemical Photo‐Oxidation of 5‐Methyl Cytidines
Author(s) -
Jin XiaoYang,
Wang RuiLi,
Xie LiJun,
Kong DeLong,
Liu Li,
Cheng Liang
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900811
Subject(s) - cytidine , chemistry , biomolecule , nucleic acid , selectivity , combinatorial chemistry , biochemistry , catalysis , enzyme
A new approach for the oxidation of 5‐methyl cytidine modification in nucleic acids to 5‐formyl cytidine is reported. This method displays excellent chemo‐/bio‐ selectivity, from which the methyl group in cytidine nucleosides could be selectively oxidized to biologically important formyl functionality without interfering with other cellular biomolecules.