Direct Synthesis of Dihydropyrrolo[2,1‐ a ]Isoquinolines through FeCl 3  Promoted Oxidative Aromatization | Zendy

Cui HaiLei | Zendy; Jiang Lu | Zendy; Tan Hao | Zendy; Liu Si | Zendy

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Direct Synthesis of Dihydropyrrolo[2,1‐ a ]Isoquinolines through FeCl 3 Promoted Oxidative Aromatization

Author(s) -

Cui HaiLei,

Jiang Lu,

Tan Hao,

Liu Si

Publication year - 2019

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201900756

Subject(s) - aromatization , chemistry , yield (engineering) , oxidative phosphorylation , cycloaddition , combinatorial chemistry , natural product , cascade , organic chemistry , catalysis , biochemistry , materials science , chromatography , metallurgy

We have developed a straightforward FeCl 3 promoted synthesis of dihydropyrrolo[2,1‐ a ]isoquinolines through formal (3+2) cycloaddition/oxidative aromatization cascade of dihydroisoquinoline with Morita‐Baylis‐Hillman carbonates (up to 96% yield). Further modifications of the obtained products were successful through simple chemical transformations providing a diverse range of natural product‐like molecules (12 examples).

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