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C−H Reactivity of the α‐Position in Nitrones and Nitronates
Author(s) -
Sukhorukov Alexey Yu.
Publication year - 2020
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900718
Subject(s) - chemistry , reactivity (psychology) , electrophile , nucleophile , context (archaeology) , organic chemistry , position (finance) , stereochemistry , combinatorial chemistry , catalysis , paleontology , alternative medicine , pathology , biology , finance , economics , medicine
The review summarizes the chemistry of nitrones and nitronates in the context of the C−H reactivity of their α‐carbon atoms. Electrophilic, nucleophilic and radical reactions leading to functionalization of the α‐position are described. Examples of the application of these processes in total synthesis are outlined.