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Cobalt(III)‐Catalyzed and Dimethyl Sulfoxide‐Involved Cross‐Coupling of Ketones and Amides for Direct Synthesis of β ‐Amino Ketones
Author(s) -
Xu Xuefeng,
Zhou Zhi,
Wang Zhipin,
Ma Xinna,
Chen Xin,
Zhang Xu,
Yu Xiyong,
Yi Wei
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900717
Subject(s) - chemistry , acetophenone , dibenzoylmethane , ketone , catalysis , substrate (aquarium) , sulfoxide , cobalt , dimethyl sulfoxide , reagent , organic chemistry , combinatorial chemistry , stereochemistry , oceanography , geology
A straightforward synthesis of β ‐amino ketones has been realized by employing ketones and amides as the substrates via cobalt(III)‐catalyzed and dimethyl sulfoxide‐involved cross‐coupling reaction. Experimental investigations revealed that the β ‐methylsulfide ketone species might be involved as the active intermediate. Diverse ketones ( e. g . acetophenone and its derivatives, heteroaryl methyl ketones and dibenzoylmethane) and amides (e. g. aromatic, aliphaticand cyclicamides) with various substitution patterns were found to be applicable to this transformation, demonstrating a broad substrate scope and excellent functional group tolerance.