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N‐Heterocyclic Carbene‐Catalyzed β ‐Indolylation of α ‐Bromoenals with Indoles
Author(s) -
Sun Shaofa,
Lang Ming,
Wang Jian
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900699
Subject(s) - chemistry , carbene , catalysis , methylene , substrate (aquarium) , combinatorial chemistry , scope (computer science) , organic chemistry , stereochemistry , computer science , oceanography , programming language , geology
An unprecedented example of NHC‐catalyzed β ‐indolylation of α ‐bromoenals with indoles has been developed. This concise protocol features several advantages (mild reaction conditions, broad substrate scope) and constructs synthetically useful building blocks, namely β ‐biaryl methylene esters. Notably, the β ‐biaryl methylene‐type fragment is widely found in natural products or pharmaceuticals.