N‐Heterocyclic Carbene‐Catalyzed  β ‐Indolylation of  α ‐Bromoenals with Indoles | Zendy

Sun Shaofa | Zendy; Lang Ming | Zendy; Wang Jian | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

N‐Heterocyclic Carbene‐Catalyzed β ‐Indolylation of α ‐Bromoenals with Indoles

Author(s) -

Sun Shaofa,

Lang Ming,

Wang Jian

Publication year - 2019

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201900699

Subject(s) - chemistry , carbene , catalysis , methylene , substrate (aquarium) , combinatorial chemistry , scope (computer science) , organic chemistry , stereochemistry , computer science , oceanography , programming language , geology

An unprecedented example of NHC‐catalyzed β ‐indolylation of α ‐bromoenals with indoles has been developed. This concise protocol features several advantages (mild reaction conditions, broad substrate scope) and constructs synthetically useful building blocks, namely β ‐biaryl methylene esters. Notably, the β ‐biaryl methylene‐type fragment is widely found in natural products or pharmaceuticals.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research