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Sulfur Incorporation Using Disulfanes as the Sulfur Atom Source Enabled Metal‐Free Heteroannulation of 1,7‐Enynes
Author(s) -
Qin JingHao,
Yu JiangXi,
Li JinHeng,
An DeLie
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900621
Subject(s) - chemistry , sulfur , atom (system on chip) , metal , base (topology) , catalysis , combinatorial chemistry , organic chemistry , mathematical analysis , mathematics , computer science , embedded system
A new oxidative [2+2+1] heteroannulation of 1,7‐enynes with disulfanes promoted by Et 3 N, producing 3,3 a ‐dihydro‐thieno[3,4‐c]quinolin‐4(5 H )‐ones, is described. This reaction is achieved by using equivalent amounts of 1,7‐enynes, sulfur atoms (disulfanes), tert ‐butyl peroxybenzoate (TBPB) as an oxidant and Et 3 N as the base, and represents an unprecedented strategy to applications of disulfanes as sulfur atom sources in synthesis.