External Oxidant‐Free Oxidative Tandem Cyclization: NaI‐Catalyzed Thiolation for the Synthesis of 3‐Thiosubstituted Pyrroles | Zendy

Yuan Bingxiang | Zendy; Jiang Yong | Zendy; Qi Zhenjie | Zendy; Guan Xin | Zendy; Wang Ting | Zendy; Yan Rulong | Zendy

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External Oxidant‐Free Oxidative Tandem Cyclization: NaI‐Catalyzed Thiolation for the Synthesis of 3‐Thiosubstituted Pyrroles

Author(s) -

Yuan Bingxiang,

Jiang Yong,

Qi Zhenjie,

Guan Xin,

Wang Ting,

Yan Rulong

Publication year - 2019

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201900620

Subject(s) - chemistry , tandem , functional group , catalysis , combinatorial chemistry , pyrrole , oxidative phosphorylation , transformation (genetics) , organic chemistry , biochemistry , materials science , composite material , gene , polymer

A simple method for the synthesis of 3‐thiosubstituted pyrroles from homopropargylic amines and thiosulfonates via a tandem sulfenylation/cyclization has been developed. The thiosulfonates are used both as substrates and oxidants in this transformation. This procedure exhibits good functional group tolerance and a series of 3‐thiosubstituted pyrrole derivatives was obtained in moderate to good yields.

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