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External Oxidant‐Free Oxidative Tandem Cyclization: NaI‐Catalyzed Thiolation for the Synthesis of 3‐Thiosubstituted Pyrroles
Author(s) -
Yuan Bingxiang,
Jiang Yong,
Qi Zhenjie,
Guan Xin,
Wang Ting,
Yan Rulong
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900620
Subject(s) - chemistry , tandem , functional group , catalysis , combinatorial chemistry , pyrrole , oxidative phosphorylation , transformation (genetics) , organic chemistry , biochemistry , materials science , composite material , gene , polymer
A simple method for the synthesis of 3‐thiosubstituted pyrroles from homopropargylic amines and thiosulfonates via a tandem sulfenylation/cyclization has been developed. The thiosulfonates are used both as substrates and oxidants in this transformation. This procedure exhibits good functional group tolerance and a series of 3‐thiosubstituted pyrrole derivatives was obtained in moderate to good yields.