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Cover Picture: Alkylation of Terminal Alkynes under Zinc Lewis Acid Catalysis and Its Mechanistic Studies (Adv. Synth. Catal. 12/2019)
Author(s) -
Osano Mana,
Kida Takeru,
Yonekura Kyohei,
Tsuchimoto Teruhisa
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900598
Subject(s) - chemistry , alkylation , alkyl , lewis acids and bases , medicinal chemistry , catalysis , organic chemistry
The inside cover picture , designed by Teruhisa Tsuchimoto and co‐workers, illustrates that Zn(NNf 2 ) 2 (Nf=SO 2 C 4 F 9 ) catalyzes the alkylation of terminal alkynes with alkyl triflates (TfO–alkyl) in the presence of proton sponge. This is the first Lewis acid catalysis to introduce alkyl groups other than benzylic and norbornyl frameworks onto the alkynyl carbon atom. Since none of C( sp 3 )–I, C( sp 3 )–Br, and C( sp 3 )–Cl moieties participate in the alkylation, TfO‐selective alkylation can be achieved. Details of this work can be found in the communication on pages 2825–2831 (M. Osano, T. Kida, K. Yonekura, T. Tsuchimoto, Adv. Synth. Catal . 2019 , 361 , 2825–2831; DOI: 10.1002/adsc.201801685).