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Iridium‐Catalyzed ortho‐ C−H Amidation of Benzenesulfonamides with Sulfonyl Azides
Author(s) -
Hou Hongcen,
Zhao Yongli,
Sheng Shouri,
Chen Junmin
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900573
Subject(s) - chemistry , sulfonyl , iridium , catalysis , combinatorial chemistry , substrate (aquarium) , scope (computer science) , reaction mechanism , organic chemistry , alkyl , oceanography , computer science , programming language , geology
We developed herein an iridium‐catalyzed direct C−H activation/ C−N bond formation reaction of benzenesulfonamides with sulfonyl azides. The amidation reaction provides a protocol for the synthesis of 2‐aminobenzesulfonamides in good to excellent yields. This strategy features a wide substrate scope, tolerates a broad range of functional groups under external oxidant‐free conditions and only releases molecular nitrogen as the sole by‐product. Moreover, the preliminary mechanism was investigated and the proposed reaction pathway was provided.