Enantioselective Synthesis of 2‐Hydroxyalkyl Diarylphosphinates by Ruthenium‐Catalyzed Asymmetric Transfer Hydrogenation | Zendy

Zhang Kaili | Zendy; Yang Yuping | Zendy; Liu Huan | Zendy; Liu Qixing | Zendy; Lv Jinliang | Zendy; Zhou Haifeng | Zendy

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Enantioselective Synthesis of 2‐Hydroxyalkyl Diarylphosphinates by Ruthenium‐Catalyzed Asymmetric Transfer Hydrogenation

Author(s) -

Zhang Kaili,

Yang Yuping,

Liu Huan,

Liu Qixing,

Lv Jinliang,

Zhou Haifeng

Publication year - 2019

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201900569

Subject(s) - chemistry , enantioselective synthesis , ruthenium , transfer hydrogenation , catalysis , enantiomer , noyori asymmetric hydrogenation , diamine , enantiomeric excess , absolute configuration , asymmetric hydrogenation , alkyl , organic chemistry , combinatorial chemistry

An asymmetric transfer hydrogenation of 2‐oxo alkyl phosphinates in the presence of a chiral diamine ruthenium catalyst with HCOONa as a hydrogen source in aqueous 2,2,2‐trifluoroethanol under mild conditions gave a wide range of chiral 2‐hydroxyalkyl diarylphosphinates in enantiomeric excesses of 97–99% and in good yields. The absolute configuration of the products was determined to be R by single‐crystal X‐ray diffraction.

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