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Enantioselective Synthesis of 2‐Hydroxyalkyl Diarylphosphinates by Ruthenium‐Catalyzed Asymmetric Transfer Hydrogenation
Author(s) -
Zhang Kaili,
Yang Yuping,
Liu Huan,
Liu Qixing,
Lv Jinliang,
Zhou Haifeng
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900569
Subject(s) - chemistry , enantioselective synthesis , ruthenium , transfer hydrogenation , catalysis , enantiomer , noyori asymmetric hydrogenation , diamine , enantiomeric excess , absolute configuration , asymmetric hydrogenation , alkyl , organic chemistry , combinatorial chemistry
An asymmetric transfer hydrogenation of 2‐oxo alkyl phosphinates in the presence of a chiral diamine ruthenium catalyst with HCOONa as a hydrogen source in aqueous 2,2,2‐trifluoroethanol under mild conditions gave a wide range of chiral 2‐hydroxyalkyl diarylphosphinates in enantiomeric excesses of 97–99% and in good yields. The absolute configuration of the products was determined to be R by single‐crystal X‐ray diffraction.