Premium
Formation of Carbon‐Carbon Double Bonds: Recent Developments via Nitrous Acid Elimination (NAE) from Aliphatic Nitro Compounds
Author(s) -
Ballini Roberto,
Palmieri Alessandro
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900563
Subject(s) - chemistry , nitro , nitrous acid , organic chemistry , double bond , carbon fibers , combinatorial chemistry , alkyl , materials science , composite number , composite material
Aliphatic nitro compounds having an acidic hydrogen in the β‐position, with respect to the nitro group, are prone to undergo the elimination of nitrous acid, mainly under basic conditions, affording a C=C double bond. Until a few decades ago, the literature reported some examples of the application of this elimination as a strategic step in the synthesis of a variety of important targets. However, mainly in the last two decades, this methodology has been largely developed and applied, thus the aim of this review is to report the most important recent improvements.