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Brønsted Acid‐Catalyzed Asymmetric Ring‐Closing Alkylation of Inert N‐substituted Pyrroles with α, β‐Unsaturated Ketones
Author(s) -
Wei Zhao,
Zhang Jinlong,
Yang Huameng,
Jiang Gaoxi
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900546
Subject(s) - chemistry , alkylation , intramolecular force , catalysis , ring (chemistry) , brønsted–lowry acid–base theory , medicinal chemistry , inert , closing (real estate) , organic chemistry , political science , law
A Chiral Brønsted acid catalyzed asymmetric intramolecular ring‐closing alkylation of inert pyrroles with α, β‐unsaturated ketones has been developed. This approach gave a wide range of 4‐phenyl‐4,5‐dihydro‐6H‐benzo[f]pyrrolo[1,2‐a]azepin‐6‐ones in high yields with good enantioselectivities under mild reaction conditions.