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Metal‐Free [3,3]‐Sigmatropic Rearrangement/[3+2] Annulation Cascade of N ‐Phenoxy Amides with Terminal Alkynes for the Diastereoselective Synthesis of trans ‐Dihydrobenzofurans
Author(s) -
Liu FuXiaomin,
Chen Weijie,
Zhu Guoxun,
Zhou Zhi,
Gao Hui,
Yi Wei
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900527
Subject(s) - annulation , chemistry , sigmatropic reaction , cascade , stereochemistry , combinatorial chemistry , metal , organic chemistry , catalysis , chromatography
An efficient synthetic route for the diastereoselective construction of trans ‐dihydrobenzofurans via cascade [3,3]‐sigmatropic rearrangement/[3+2] annulation sequences has been developed. This protocol represents a metal‐free transformation of the promising N ‐phenoxy amides with terminal alkynes and features mild conditions, good functional group compatibility, and practical synthetic potential.