Metal‐Free [3,3]‐Sigmatropic Rearrangement/[3+2] Annulation Cascade of  N ‐Phenoxy Amides with Terminal Alkynes for the Diastereoselective Synthesis of  trans ‐Dihydrobenzofurans | Zendy

Liu FuXiaomin | Zendy; Chen Weijie | Zendy; Zhu Guoxun | Zendy; Zhou Zhi | Zendy; Gao Hui | Zendy; Yi Wei | Zendy

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Metal‐Free [3,3]‐Sigmatropic Rearrangement/[3+2] Annulation Cascade of N ‐Phenoxy Amides with Terminal Alkynes for the Diastereoselective Synthesis of trans ‐Dihydrobenzofurans

Author(s) -

Liu FuXiaomin,

Chen Weijie,

Zhu Guoxun,

Zhou Zhi,

Gao Hui,

Yi Wei

Publication year - 2019

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201900527

Subject(s) - annulation , chemistry , sigmatropic reaction , cascade , stereochemistry , combinatorial chemistry , metal , organic chemistry , catalysis , chromatography

An efficient synthetic route for the diastereoselective construction of trans ‐dihydrobenzofurans via cascade [3,3]‐sigmatropic rearrangement/[3+2] annulation sequences has been developed. This protocol represents a metal‐free transformation of the promising N ‐phenoxy amides with terminal alkynes and features mild conditions, good functional group compatibility, and practical synthetic potential.

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