Rhodium(III)‐Catalyzed Regioselective C−H Activation/Annulation for the Diverse Pyrazole‐Core Substituted Furans | Zendy

Cai Hongyun | Zendy; Thombal Raju S. | Zendy; Li Xin | Zendy; Lee Yong Rok | Zendy

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Rhodium(III)‐Catalyzed Regioselective C−H Activation/Annulation for the Diverse Pyrazole‐Core Substituted Furans

Author(s) -

Cai Hongyun,

Thombal Raju S.,

Li Xin,

Lee Yong Rok

Publication year - 2019

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201900498

Subject(s) - regioselectivity , chemistry , rhodium , annulation , pyrazole , intramolecular force , indazole , combinatorial chemistry , catalysis , carbene , cascade reaction , stereochemistry , organic chemistry

A novel and facile regioselective synthetic method for polyfunctionalized furans involving rhodium(III)‐catalyzed pyrazole‐ or indazole‐directed dual C−H functionalization with diazodicarbonyls has been developed. This strategy provides rapid access to diverse tetrasubstituted furans bearing various pyrazoles or indazoles. This unprecedented one‐pot protocol proceeds via cascade C−H activation, metal‐carbene formation, migratory insertion, intramolecular cyclization, and deprotonation.

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