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Cyclisation Reactions Involving Alkyl Enol Ethers
Author(s) -
Lempenauer Luisa,
Lemière Gilles,
Duñach Elisabet
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900478
Subject(s) - enol , chemistry , enol ether , intramolecular force , silyl enol ether , alkyl , silylation , reactivity (psychology) , organic chemistry , catalysis , medicine , alternative medicine , pathology
Enol ethers are a fascinating product class and valuable building blocks with versatile reactivities and synthetic applications. With the emergence of silyl enol ethers, the chemistry of simple alkyl enol ethers has received less attention and targeted reviews of their chemistry are scarce. Especially intramolecular reactions under participation of an enol ether function have never been specifically surveyed. The construction of cyclic scaffolds is arguably one of the most important and challenging tasks of the organic chemist and intramolecular cyclisations represent the most straight‐forward tool to achieve this goal. The potential of enol ether‐containing substrates to form oxygenated carbo‐ and heterocycles is obvious. The purpose of this review is to discuss their particular reactivity and to direct the reader's attention to how their unique properties have been harnessed by organic chemists for the construction of rings.