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Rhodium‐Catalyzed Cascade Annulation of Benzimidates and Nitroalkenes for the Synthesis of Difunctionalized Indenes
Author(s) -
Lv Ningning,
Chen Zhengkai,
Liu Yue,
Liu Zhanxiang,
Zhang Yuhong
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900427
Subject(s) - chemistry , indene , rhodium , annulation , reactivity (psychology) , catalysis , combinatorial chemistry , cascade , organic chemistry , medicine , alternative medicine , pathology , chromatography
A facile and expeditious protocol for the synthesis of difunctionalized indenes from readily available benzimidates and nitroalkenes through rhodium‐catalyzed C−H activation and cyclization is reported here. The transformation exhibits powerful reactivity, tolerates a large number of functional groups, and proceeds in moderate to high yields under an ambient atmosphere, providing a straightforward method to access structurally diverse and valuable difunctionalized indene derivatives.