Premium
Iron‐Catalyzed Cross‐Dehydrogenative Coupling of Oxindoles with Thiols/Selenols for Direct C( sp 3 )−S/Se Bond Formation
Author(s) -
Huang LuShan,
Han DongYang,
Xu DaZhen
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900400
Subject(s) - chemistry , catalysis , pyrazolones , combinatorial chemistry , molecule , coupling reaction , polymer chemistry , photochemistry , medicinal chemistry , organic chemistry
The C−X (S/Se) bonds are common and ubiquitous in natural products and pharmaceuticals. Here, we report an iron‐catalyzed cross‐dehydrogenative coupling (CDC) reaction for the direct synthesis of C( sp 3 )−X (S/Se) bonds from oxindoles, phenylacetamides, pyrazolones, phenylacetonitriles and ethyl cyanoacetate with thiols and selenols. All the reactions were performed under simple and mild conditions, and air (molecular oxygen) was employed as an ideal green oxidant, thus promising broad application in chemical industry and modification of bioactive molecules.