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Isomerization of Epoxides
Author(s) -
Jat Jawahar L.,
Kumar Ganesh
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900392
Subject(s) - isomerization , chemistry , ring (chemistry) , regioselectivity , epoxide , organic chemistry , combinatorial chemistry , catalysis
Epoxides are highly useful synthetic intermediates and they can be synthesized stereo‐ and regioselectively. Due to the strained three‐membered ring, their synthetic utility is limited. In many cases, it would be better to transform epoxides to other stable functional groups which could be used further in the synthesis. This isomerization would offer an alternate pathway to utilize the synthetic potential of epoxides. Despite the potential of such isomerization reactions, they have not been widely explored by chemists. In this review, the methods to isomerize epoxides into stable functional groups such as alcohols, aldehydes, ketones as well as trans ‐epoxides, both stereo‐ and regioselectively, are discussed.