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Rhodium‐Catalyzed Asymmetric [2+2+2] Cycloaddition Reactions of 1,6‐Enynes and Oxabenzonorbornadienes
Author(s) -
Ni Jianxiao,
Chen Jingchao,
Zhou Yongyun,
Wang Gaowei,
Li Sida,
He Zhenxiu,
Sun Weiqing,
Fan Baomin
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900380
Subject(s) - cycloaddition , chemistry , rhodium , catalysis , enantioselective synthesis , medicinal chemistry , organic chemistry
The asymmetric [2+2+2] cycloaddition reactions of 1,6‐enynes and oxabenzonorbornadienes was accomplished by using the complex of [Rh(COD) 2 ]BF 4 and ( R )‐Xyl‐P‐Phos as chiral catalyst. A range of 1,6‐enynes and oxabenzonorbornadienes were well tolerated in the cycloaddition reaction, which afforded various polycyclic products with asymmetric quaternary carbon centers generally in excellent enantioselectivities.