Premium
Cross‐Dehydrogenative C−O Coupling of Oximes with Acetonitrile, Ketones and Esters
Author(s) -
Chen ZhenYu,
Liang HuaJu,
Chen RiXing,
Chen Lei,
Tang XiangZheng,
Yan Ming,
Zhang XueJing
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900370
Subject(s) - chemistry , acetonitrile , iodide , photochemistry , kinetics , acceptor , organic chemistry , physics , condensed matter physics , quantum mechanics
A transition metal‐free approach for the generation of radical intermediates via EDA complexes had been developed. This approach enables a cross‐dehydrogenative C−O coupling of oximes with acetonitrile, ketones and esters with high yields and regioselectivities. Perfluorobutyl iodide was used as the unique electron acceptor to trigger a new radical formation. The radical pathway was confirmed by UV‐Vis spectroscopy, radical inhibiting, trapping and kinetics experiments.