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Palladium(II)‐Catalyzed Intermolecular Cascade Cyclization of Methylenecyclopropanes with Aromatic Alkynes: Construction of Spirocyclic Compounds Containing Indene and 1,2‐Dihydronaphthalene Moieties
Author(s) -
Fang Wei,
Wei Yin,
Shi Min
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900327
Subject(s) - indene , chemistry , intramolecular force , palladium , intermolecular force , alkyne , catalysis , cascade , cascade reaction , medicinal chemistry , organic chemistry , molecule , chromatography
A palladium(II)‐catalyzed intermolecular cascade cyclization of methylenecyclopropanes with aromatic alkynes is reported in this paper. The reaction involves a migratory insertion of alkyne, an intramolecular Heck‐type reaction, and β‐H elimination, providing a series of spirocyclic compounds containing indene and 1,2‐dihydronaphthalene moieties in moderate to excellent yields upon heating.