Rh(III)‐Catalyzed Distal C‐H Alkenylation of Weakly Coordinating Acetamides Via Desilylation Pathway | Zendy

Ramesh Vinay Bapu | Zendy; Muniraj Nachimuthu | Zendy; Prabhu Kandikere Ramaiah | Zendy

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Rh(III)‐Catalyzed Distal C‐H Alkenylation of Weakly Coordinating Acetamides Via Desilylation Pathway

Author(s) -

Ramesh Vinay Bapu,

Muniraj Nachimuthu,

Prabhu Kandikere Ramaiah

Publication year - 2019

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201900307

Subject(s) - chemistry , silanes , acetamide , catalysis , silylation , redox , medicinal chemistry , stereochemistry , organic chemistry , silane

Rh(III)‐Catalyzed distal ortho ‐C−H alkenylation of arylacetamides have been reported employing acetamide, a weak coordinating group, as a directing group. This challenging C−H alkenylation of arylacetamides has been achieved by using arylalkynyl silanes as a surrogate for terminal alkynes under redox neutral process through desilylation pathway. The control experiments suggest that the in situ generatedRh‐species is likely to be Lewis acidic, which is playing a vital role in the desilylation step.

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