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Palladium‐Catalyzed Inert C−H Bond Activation and Cyclocarbonylation of Isoquinolones with Carbon Dioxide Leading to Isoindolo[2,1‐ b ]isoquinoline‐5,7‐Diones
Author(s) -
Yan Kelu,
Jin Junbin,
Kong Yong,
Li Bin,
Wang Baiquan
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900305
Subject(s) - isoquinoline , chemistry , palladium , catalysis , selectivity , inert , medicinal chemistry , functional group , inert gas , carbon dioxide , organic chemistry , combinatorial chemistry , polymer
A palladium‐catalyzed inert C−H bond activation and cyclocarbonylation of isoquinolones leading to isoindolo[2,1‐ b ]isoquinoline‐5,7‐diones under 1 atm of carbon dioxide has been developed. This transformation features high regio‐ and chemo‐selectivity, step‐economy, and good functional group tolerance. Most of the corresponding products were obtained in moderate to good yields. It offers an alternative approach for the synthesis of useful diverse isoindolo[2,1‐ b ]isoquinoline‐5,7‐dione derivatives.