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Rh(III)‐Catalyzed Aldehydic C−H Functionalization Reaction between Salicylaldehydes and Sulfoxonium Ylides
Author(s) -
Xu GuoDong,
Huang Kenneth L.,
Huang ZhiZhen
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900276
Subject(s) - chemistry , rhodium , surface modification , carbene , catalysis , combinatorial chemistry , medicinal chemistry , organic chemistry
A novel aldehydic C−H functionalization reaction between salicylaldehydes and sulfoxonium ylides has been developed under rhodium(III) catalysis, affording coupling products in moderate to good yields. A plausible mechanism involving aldehydic C( sp 2 )−H activation by rhodium(III) and rhodium(III) catalyzed carbene insertion is also proposed. It was also found that the aldehydic C−H functionalization followed by dehydrative cyclization was able to produce flavonoids in one‐pot.