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Gold(III)‐Catalyzed Intermolecular Oxidation‐Cyclization of Ynones: Access to 4‐Substituted Chroman‐3‐ones
Author(s) -
Li Jian,
Yang Fang,
Ma YangTing,
Ji Kegong
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900260
Subject(s) - chemistry , alkyne , alkene , catalysis , yield (engineering) , combinatorial chemistry , halide , intermolecular force , cascade , organic chemistry , molecule , materials science , chromatography , metallurgy
A synthesis of 4‐substituted chroman‐3‐one derivatives has been developed through a gold(III) catalyzed oxidation‐cyclization of ynones in good to excellent yield using easily prepared substrates. A broad range of synthetically useful functional groups (halide, alkene, alkyne, phenolic hydroxyl) were tolerated. Further application of this method paves a new way to prepare the skeleton of oblarotenoids. A cascade oxidative cyclization for construction of pyrano[2,3‐c]chromen‐1(5H)‐one derivatives is also presented.