Synthesis of Tridentate Chiral Spiro Aminophosphine−Oxazoline Ligands and Application to Asymmetric Hydrogenation of α‐Keto Amides | Zendy

Zhang FengHua | Zendy; Wang Chen | Zendy; Xie JianHua | Zendy; Zhou QiLin | Zendy

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Synthesis of Tridentate Chiral Spiro Aminophosphine−Oxazoline Ligands and Application to Asymmetric Hydrogenation of α‐Keto Amides

Author(s) -

Zhang FengHua,

Wang Chen,

Xie JianHua,

Zhou QiLin

Publication year - 2019

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201900251

Subject(s) - chemistry , oxazoline , asymmetric hydrogenation , combinatorial chemistry , enantioselective synthesis , stereochemistry , organic chemistry , catalysis

A new type of tridentate chiral spiro aminophosphine−oxazoline ligands (SpiroOAP) have been synthesized through four steps. The SpiroOAP ligands are highly efficient for the asymmetric hydrogenation of α‐keto amides, providing a variety of synthetically useful α‐hydroxy amides with excellent enantioselectivity (up to 98% ee) and turnover numbers (up to 10,000).

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