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Front Cover Picture: Gold Catalyzed Photoredox C1‐Alkynylation of N ‐Alkyl‐1,2,3,4‐tetrahydroisoquinolines by 1‐Bromoalkynes with UVA LED Light (Adv. Synth. Catal. 6/2019)
Author(s) -
Zhao Yichao,
Jin Jianwen,
Chan Philip Wai Hong
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900238
Subject(s) - chemistry , front cover , alkyl , regioselectivity , alkynylation , photosensitizer , photoredox catalysis , reactivity (psychology) , alkyne , photochemistry , catalysis , medicinal chemistry , dimer , cationic polymerization , visible spectrum , stereochemistry , cover (algebra) , organic chemistry , photocatalysis , optoelectronics , mechanical engineering , medicine , alternative medicine , pathology , engineering , physics
Reactivity at the flick of a light switch . The front cover picture , provided by Chan and co‐workers, illustrates how [Au 2 ( μ ‐dppm) 2 ]Cl 2 [dppm = bis(diphenylphosphanyl)methane] becomes a highly efficient photosensitizer on exposure to UVA LED (LED = light emitting diode) light (365 nm). Achieved under redox‐neutral reaction conditions at room temperature, the Group 11 dimer complex was shown to mediate the regioselective C1‐alkynylation of N ‐alkyl‐1,2,3,4‐tetrahydroisoquinolines with alkynyl bromides in moderate to excellent product yields. Details of this work can be found in the full paper on pages 1313–1321 (Y. Zhao, J. Jin, P. W. H. Chan, Adv. Synth. Catal . 2019 , 361 , 1313–1321; DOI: 10.1002/adsc.201801289).