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Pd‐Catalyzed Tandem Coupling Reaction of 2‐ gem ‐Dibromovinylanilines and N ‐Tosylhydrazones to Construct 2‐(1‐phenylvinyl)‐indoles
Author(s) -
Song Jian,
Chi Xiaochen,
Meng Long,
Zhao Pingping,
Sun Fenggang,
Zhang Daopeng,
Jiao Luyang,
Liu Qing,
Dong Yunhui,
Liu Hui
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900230
Subject(s) - chemistry , indole test , intermolecular force , tandem , catalysis , substrate (aquarium) , coupling (piping) , construct (python library) , combinatorial chemistry , coupling reaction , molecule , organic chemistry , mechanical engineering , materials science , oceanography , computer science , engineering , composite material , programming language , geology
A novel palladium(0)‐catalyzed intermolecular coupling reaction of 2‐ gem ‐dibromovinylanilines and N ‐tosylhydrazones was reported to construct 2‐(1‐phenylvinyl)‐indoles efficiently. The indole bearing 1, 1‐disubstituted alkenes were obtained in one step with short reaction time, in high yields and broad substrate scope. The formed indole derivates could be easily transformed into much more valuable molecules.