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Four Pathways in Radical Alkylation of Isocyanide with Simple Alcohol
Author(s) -
Liu Shuai,
Fan Fenghua,
Wang Nengyong,
Yuan Dandan,
Wang Yaxin,
Luo Zaigang,
Liu ZhongQuan
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900221
Subject(s) - chemistry , isocyanide , alkylation , alcohol , simple (philosophy) , computational chemistry , organic chemistry , photochemistry , catalysis , philosophy , epistemology
We demonstrated herein the four modes in free‐radical C−C formation reaction of isocyanide with alcohol. The experimental results and DFT calculation revealed when and why one model opens. It would be instructive and valuable for radical alkylation with alcohol in organic synthesis.