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Cobalt(III)/Rhodium(III)‐Catalyzed Regio‐ and Stereoselective Allylation of 8‐Methylquinoline via sp 3 C−H Activation
Author(s) -
Li Na,
Wang Yahui,
Kong Lingheng,
Chang Junbiao,
Li Xingwei
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900220
Subject(s) - chemistry , stereoselectivity , rhodium , cobalt , catalysis , regioselectivity , medicinal chemistry , cleavage (geology) , stereochemistry , organic chemistry , fracture (geology) , engineering , geotechnical engineering
Regio‐ and stereoselective benzylic allylation of 8‐methylquinolines with (per)fluoroalkyl olefins has been realized via benzylic C−H activation and subsequent C−F cleavage. Both cobalt(III) and rhodium(III) catalysts can effect this transformation in good to high efficiency. The Rh(III)‐catalyzed system proceeded under moderate conditions with decent substrates scope, providing ( Z )‐alkenyl fluorides with good to excellent regio‐ and stereoselectivity.