Cobalt(III)/Rhodium(III)‐Catalyzed Regio‐ and Stereoselective Allylation of 8‐Methylquinoline via  sp  3  C−H Activation | Zendy

Li Na | Zendy; Wang Yahui | Zendy; Kong Lingheng | Zendy; Chang Junbiao | Zendy; Li Xingwei | Zendy

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Cobalt(III)/Rhodium(III)‐Catalyzed Regio‐ and Stereoselective Allylation of 8‐Methylquinoline via sp 3 C−H Activation

Author(s) -

Li Na,

Wang Yahui,

Kong Lingheng,

Chang Junbiao,

Li Xingwei

Publication year - 2019

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201900220

Subject(s) - chemistry , stereoselectivity , rhodium , cobalt , catalysis , regioselectivity , medicinal chemistry , cleavage (geology) , stereochemistry , organic chemistry , fracture (geology) , engineering , geotechnical engineering

Regio‐ and stereoselective benzylic allylation of 8‐methylquinolines with (per)fluoroalkyl olefins has been realized via benzylic C−H activation and subsequent C−F cleavage. Both cobalt(III) and rhodium(III) catalysts can effect this transformation in good to high efficiency. The Rh(III)‐catalyzed system proceeded under moderate conditions with decent substrates scope, providing ( Z )‐alkenyl fluorides with good to excellent regio‐ and stereoselectivity.

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