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Front Cover Picture: B(C 6 F 5 ) 3 ‐Catalyzed Deoxygenative Reduction of Amides to Amines with Ammonia Borane (Adv. Synth. Catal. 10/2019)
Author(s) -
Pan Yixiao,
Luo Zhenli,
Han Jiahong,
Xu Xin,
Chen Changjun,
Zhao Haoqiang,
Xu Lijin,
Fan Qinghua,
Xiao Jianliang
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900210
Subject(s) - chemistry , borane , amide , front cover , adduct , catalysis , medicinal chemistry , boron , ammonia , ammonia borane , amine gas treating , metal , functional group , stereochemistry , organic chemistry , cover (algebra) , mechanical engineering , polymer , engineering , hydrogen production
The front cover picture , provided by Lijin Xu and co‐workers, illustrates the first B(C 6 F 5 ) 3 ‐catalyzed reduction of amides into the corresponding amines with readily accessible and stable ammonia borane under mild reaction conditions. The role of BF 3 ⋅OEt 2 co‐catalyst is to activate the amide carbonyl group via the in situ formation of an amide‐boron adduct. This metal‐free protocol provides facile access to various amines in good to excellent yields with high functional group tolerance. Details of this work can be found in the full paper on pages 2301–2308 (Y. Pan, Z. Luo, J. Han, X. Xu, C. Chen, H. Zhao, L. Xu, Q. Fan, J. Xiao, Adv. Synth. Catal . 2019 , 361 , 2301–2308; DOI: 10.1002/adsc.201801447).