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Chiral N , N ′‐Dioxide/Tm(OTf) 3 Complex‐Catalyzed Asymmetric Bisvinylogous Mannich Reaction of Silyl Ketene Acetal with Aldimines
Author(s) -
Zou Sijia,
Li Weiwei,
Fu Kai,
Cao Weidi,
Lin Lili,
Feng Xiaoming
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900164
Subject(s) - ketene , aldimine , acetal , chemistry , silylation , enantioselective synthesis , mannich reaction , catalysis , diethylzinc , organic chemistry , medicinal chemistry
An enantioselective bisvinylogous Mannich reaction of silyl ketene acetal with aldimines has been realized by using a chiral N , N ′‐dioxide/Tm(OTf) 3 complex as catalyst, providing an effective method to synthesize chiral ζ‐ amino ‐α,β,γ,δ‐ unsaturated carbonyl compounds.