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Elemental Sulfur/DMSO‐Promoted Multicomponent One‐pot Synthesis of Malonic Acid Derivatives from Maleic Anhydride and Amines
Author(s) -
Nguyen Le Anh,
Retailleau Pascal,
Nguyen Thanh Binh
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900160
Subject(s) - chemistry , maleic anhydride , malonic acid , sulfur , organic chemistry , condensation , elemental analysis , decarboxylation , polymer chemistry , catalysis , polymer , copolymer , physics , thermodynamics
Malonic acid derivatives could be conveniently prepared with high degree of functional flexibility via redox condensation reactions between anhydride maleic, amines, elemental sulfur and DMSO as oxidant. This multicomponent decarboxylative transformation consists in a cascade of ring opening, decarboxylative oxidative thioamidation at temperature as low as 50 °C.