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Synthesis of Polycyclic Quinolines by Means of Brønsted Acid Mediated Reaction of β‐(2‐Aminophenyl)‐α,β‐Ynones with Ketones
Author(s) -
Marsicano Vincenzo,
Chiarini Marco,
Marinelli Fabio,
Arcadi Antonio
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900141
Subject(s) - chemistry , aromatization , annulation , brønsted–lowry acid–base theory , organic chemistry , methylene , combinatorial chemistry , cycloisomerization , amination , catalysis
Sequential Brønsted acid promoted amination/annulation/aromatization of β‐(2‐aminophenyl)‐α,β‐ynones with cyclic α‐methylene carbonyl compounds has been developed for the synthesis of polycyclic quinolines in good to high yields in ethanol. The protocol achieves the selective formation of the target quinolines and is expected to find practical applications due to its operational simplicity.