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Phosphine‐Catalyzed Intermolecular Annulations of Fluorinated ortho ‐Aminophenones with Alkynones – The Switchable [4+2] or [4+2]/[3+2] Cycloaddition
Author(s) -
Zhang Yanshun,
Sun Yaoliang,
Wei Yin,
Shi Min
Publication year - 2019
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201900082
Subject(s) - chemistry , phosphine , annulation , catalysis , intermolecular force , indolizine , cycloaddition , organic chemistry , combinatorial chemistry , medicinal chemistry , molecule
A phosphine‐catalyzed intermolecular annulation reaction of functionalized ortho ‐aminoacetophenones with alkynones has been disclosed in this paper. A variety of 2‐alkynylquinolines and benzo‐fused indolizine were selectively afforded in moderate to good yields at different reaction temperatures and with different phosphine catalysts via the in situ generated zwitterionic intermediate derived from alkynone and phosphine.